7WYP

Structure of the SARS-COV-2 main protease with EN102 inhibitor

7WYP の概要

• エントリーDOI: 10.2210/pdb7wyp/pdb
• 分子名称: 3C-like proteinase, N-(1,3-benzothiazol-2-ylmethyl)-N-cyclopropyl-prop-2-enamide (3 entities in total)
• 機能のキーワード: structure of the sars-cov-2 main protease with en102 inhibitor, viral protein
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 68167.77

構造登録者

Qin, B.,Hou, P.,Gao, X.,Cui, S. (登録日: 2022-02-16, 公開日: 2022-06-22, 最終更新日: 2023-11-29)

• 主引用文献: Qin, B.,Craven, G.B.,Hou, P.,Chesti, J.,Lu, X.,Child, E.S.,Morgan, R.M.L.,Niu, W.,Zhao, L.,Armstrong, A.,Mann, D.J.,Cui, S.; Acrylamide fragment inhibitors that induce unprecedented conformational distortions in enterovirus 71 3C and SARS-CoV-2 main protease.; Acta Pharm Sin B, 12:3924-3933, 2022; PubMed: 35702321; DOI: 10.1016/j.apsb.2022.06.002

実験手法

X-RAY DIFFRACTION (2.3 Å)