7WWZ

BRD4-BD1 complexed with NEO2734

7WWZ の概要

• エントリーDOI: 10.2210/pdb7wwz/pdb
• 分子名称: Isoform C of Bromodomain-containing protein 4, 1,3-dimethyl-5-[2-(oxan-4-yl)-3-[2-(trifluoromethyloxy)ethyl]benzimidazol-5-yl]pyridin-2-one (3 entities in total)
• 機能のキーワード: brd4, bromodomain, neo2734, complex, structural protein
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 15403.62

構造登録者

Zeng, L.,Lei, J.D. (登録日: 2022-02-14, 公開日: 2022-06-08, 最終更新日: 2023-11-29)

• 主引用文献: Ji, D.,Shang, G.,Wei, E.,Jia, Y.,Wang, C.,Zhang, Q.,Zeng, L.; Targeting CDCP1 gene transcription coactivated by BRD4 and CBP/p300 in castration-resistant prostate cancer.; Oncogene, 41:3251-3262, 2022; PubMed: 35513563; DOI: 10.1038/s41388-022-02327-5

実験手法

X-RAY DIFFRACTION (1.16 Å)