7WVM

The complex structure of PD-1 and cemiplimab

7WVM の概要

• エントリーDOI: 10.2210/pdb7wvm/pdb
• 分子名称: Heavy Chain of Cemiplimab, Light Chain of Cemiplimab, Programmed cell death protein 1 (3 entities in total)
• 機能のキーワード: pd-1, antibody, n58 glycosylation, cemiplimab, immune checkpoint therapy (ict), antitumor protein, immune system-antitumor protein complex, immune system/antitumor protein
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 74873.37

構造登録者

Lu, D.,Xu, Z.P.,Liu, K.F.,Tan, S.G.,Gao, G.F.,Chai, Y. (登録日: 2022-02-10, 公開日: 2022-04-20, 最終更新日: 2023-11-29)

• 主引用文献: Lu, D.,Xu, Z.,Zhang, D.,Jiang, M.,Liu, K.,He, J.,Ma, D.,Ma, X.,Tan, S.,Gao, G.F.,Chai, Y.; PD-1 N58-Glycosylation-Dependent Binding of Monoclonal Antibody Cemiplimab for Immune Checkpoint Therapy.; Front Immunol, 13:826045-826045, 2022; PubMed: 35309324; DOI: 10.3389/fimmu.2022.826045

実験手法

X-RAY DIFFRACTION (3.4 Å)