7WRK

Structure of hypothetical protein TTHA1873 from Thermus thermophilus

7WRK の概要

• エントリーDOI: 10.2210/pdb7wrk/pdb
• 分子名称: hypothetical protein TTHA1873, CALCIUM ION (3 entities in total)
• 機能のキーワード: unknown function
• 由来する生物種: Thermus thermophilus HB8
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 18556.34

構造登録者

Yuvaraj, I.,Santosh, K.C.,Sekar, K. (登録日: 2022-01-27, 公開日: 2022-03-09, 最終更新日: 2024-05-29)

主引用文献

Yuvaraj, I.,Chaudhary, S.K.,Jeyakanthan, J.,Sekar, K.
Structure of the hypothetical protein TTHA1873 from Thermus thermophilus.
Acta Crystallogr.,Sect.F, 78:338-346, 2022

PubMed Abstract: The crystal structure of an uncharacterized hypothetical protein, TTHA1873 from Thermus thermophilus, has been determined by X-ray crystallography to a resolution of 1.78 Å using the single-wavelength anomalous dispersion method. The protein crystallized as a dimer in two space groups: P422 and P622. Structural analysis of the hypothetical protein revealed that the overall fold of TTHA1873 has a β-sandwich jelly-roll topology with nine β-strands. TTHA1873 is a dimeric metal-binding protein that binds to two Ca ions per chain, with one on the surface and the other stabilizing the dimeric interface of the two chains. A structural homology search indicates that the protein has moderate structural similarity to one domain of cell-surface proteins or agglutinin receptor proteins. Red blood cells showed visible agglutination at high concentrations of the hypothetical protein.

PubMed: 36048084
DOI: 10.1107/S2053230X22008457

実験手法

X-RAY DIFFRACTION (1.78 Å)