7WNX

Cryo-EM structure of Mycobacterium smegmatis MmpL3 complexed with ST004 in lipid nanodiscs

7WNX の概要

• エントリーDOI: 10.2210/pdb7wnx/pdb
• EMDBエントリー: 32634
• 分子名称: Trehalose monomycolate exporter MmpL3, N-[2-(2-adamantylamino)ethyl]-1-[2,4-bis(fluoranyl)phenyl]-5-(4-chlorophenyl)-4-methyl-pyrazole-3-carboxamide (2 entities in total)
• 機能のキーワード: drug target, novel compound, mycobacterium tuberculosis, membrane protein
• 由来する生物種: Mycolicibacterium smegmatis MC2 155
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 110581.81

構造登録者

Zhang, B.,Hu, T.,Yang, X.,Liu, F.,Rao, Z. (登録日: 2022-01-20, 公開日: 2022-08-03, 最終更新日: 2024-04-10)

• 主引用文献: Hu, T.,Yang, X.,Liu, F.,Sun, S.,Xiong, Z.,Liang, J.,Yang, X.,Wang, H.,Yang, X.,Guddat, L.W.,Yang, H.,Rao, Z.,Zhang, B.; Structure-based design of anti-mycobacterial drug leads that target the mycolic acid transporter MmpL3.; Structure, 30:1395-1402.e4, 2022; PubMed: 35981536; DOI: 10.1016/j.str.2022.07.009

実験手法

ELECTRON MICROSCOPY (3.36 Å)