7WNW

Crystal structure of Imine Reductase Mutant(M5) from Actinoalloteichus hymeniacidonis in complex with NADPH

7WNW の概要

• エントリーDOI: 10.2210/pdb7wnw/pdb
• 分子名称: 3-hydroxyisobutyrate dehydrogenase-like beta-hydroxyacid dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE (3 entities in total)
• 機能のキーワード: imine reductase, nadph, ired, oxidoreductase
• 由来する生物種: Actinoalloteichus hymeniacidonis
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 72008.13

構造登録者

Zhand, J.,Chen, R.,Gao, S. (登録日: 2022-01-19, 公開日: 2022-04-06, 最終更新日: 2023-11-29)

• 主引用文献: Zhang, J.,Liao, D.,Chen, R.,Zhu, F.,Ma, Y.,Gao, L.,Qu, G.,Cui, C.,Sun, Z.,Lei, X.,Gao, S.S.; Tuning an Imine Reductase for the Asymmetric Synthesis of Azacycloalkylamines by Concise Structure-Guided Engineering.; Angew.Chem.Int.Ed.Engl., 61:e202201908-e202201908, 2022; PubMed: 35322515; DOI: 10.1002/anie.202201908

実験手法

X-RAY DIFFRACTION (2.13 Å)