7WN7

Crystal structure of HearNPV P26

7WN7 の概要

• エントリーDOI: 10.2210/pdb7wn7/pdb
• 分子名称: p26, SULFATE ION, CHLORIDE ION, ... (4 entities in total)
• 機能のキーワード: nuclease, hydrolase
• 由来する生物種: Helicoverpa armigera nucleopolyhedrovirus G4
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 68423.54

構造登録者

Kuang, W.,Hu, Z.,Gong, P. (登録日: 2022-01-17, 公開日: 2022-11-23, 最終更新日: 2024-05-29)

主引用文献

Yin, M.,Kuang, W.,Wang, Q.,Wang, X.,Yuan, C.,Lin, Z.,Zhang, H.,Deng, F.,Jiang, H.,Gong, P.,Zou, Z.,Hu, Z.,Wang, M.
Dual roles and evolutionary implications of P26/poxin in antagonizing intracellular cGAS-STING and extracellular melanization immunity.
Nat Commun, 13:6934-6934, 2022

PubMed Abstract: P26, a homolog of the viral-encoded nuclease poxin that neutralizes the cGAS-STING innate immunity, is widely distributed in various invertebrate viruses, lepidopteran insects, and parasitoid wasps. P26/poxin from certain insect viruses also retains protease activity, though its biological role remains unknown. Given that many P26s contain a signal peptide, it is surmised that P26 may possess certain extracellular functions. Here, we report that a secretory baculoviral P26 suppresses melanization, a prominent insect innate immunity against pathogen invasion. P26 targets the cofactor of a prophenoloxidase-activating protease, and its inhibitory function is independent of nuclease activity. The analysis of P26/poxin homologs from different origins suggests that the ability to inhibit the extracellular melanization pathway is limited to P26s with a signal peptide and not shared by the homologs without it. These findings highlight the independent evolution of a single viral suppressor to perform dual roles in modulating immunity during virus-host adaptation.

PubMed: 36376305
DOI: 10.1038/s41467-022-34761-0

実験手法

X-RAY DIFFRACTION (1.9 Å)