7WN1

Structure of PfNT1(Y190A) in complex with nanobody 48 and inosine

Summary for 7WN1

• Entry DOI: 10.2210/pdb7wn1/pdb
• EMDB information: 32619
• Descriptor: Equilibrative nucleoside/nucleobase transporter, nanobody48, INOSINE (3 entities in total)
• Functional Keywords: malaria, equilibrative nucleoside transporter, inosine, transport protein
• Biological source: Plasmodium falciparum (malaria parasite P. falciparum); More
• Total number of polymer chains: 2
• Total formula weight: 61047.59

Authors

Wang, C.,Deng, D.,Ren, R.B.,Yu, L.Y. (deposition date: 2022-01-17, release date: 2023-02-01, Last modification date: 2023-08-16)

• Primary citation: Wang, C.,Yu, L.,Zhang, J.,Zhou, Y.,Sun, B.,Xiao, Q.,Zhang, M.,Liu, H.,Li, J.,Li, J.,Luo, Y.,Xu, J.,Lian, Z.,Lin, J.,Wang, X.,Zhang, P.,Guo, L.,Ren, R.,Deng, D.; Structural basis of the substrate recognition and inhibition mechanism of Plasmodium falciparum nucleoside transporter PfENT1.; Nat Commun, 14:1727-1727, 2023; PubMed: 36977719; DOI: 10.1038/s41467-023-37411-1

Experimental method

ELECTRON MICROSCOPY (3.11 Å)