7WMU
Crystal Structure of the second bromodomain of human BRD2 in complex with the inhibitor Y13146
Summary for 7WMU
Entry DOI | 10.2210/pdb7wmu/pdb |
Descriptor | Isoform 4 of Bromodomain-containing protein 2, ~{N}-[4-[2,4-bis(fluoranyl)phenoxy]-3-[2-(2-cyclobutyl-1~{H}-imidazol-5-yl)-5-methyl-4-oxidanylidene-furo[3,2-c]pyridin-7-yl]phenyl]ethanesulfonamide, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | brd2-bd2, bromodomain, inhibitor, protein binding |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 16623.89 |
Authors | |
Primary citation | Li, J.,Zhang, C.,Xu, H.,Wang, C.,Dong, R.,Shen, H.,Zhuang, X.,Chen, X.,Li, Q.,Lu, J.,Zhang, M.,Wu, X.,Loomes, K.M.,Zhou, Y.,Zhang, Y.,Liu, J.,Xu, Y. Structure-Based Discovery and Optimization of Furo[3,2- c ]pyridin-4(5 H )-one Derivatives as Potent and Second Bromodomain (BD2)-Selective Bromo and Extra Terminal Domain (BET) Inhibitors. J.Med.Chem., 65:5760-5799, 2022 Cited by PubMed: 35333526DOI: 10.1021/acs.jmedchem.2c00100 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.73 Å) |
Structure validation
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