7WMC

Crystal structure of macrocyclic peptide 1 bound to human Nicotinamide N-methyltransferase

Summary for 7WMC

• Entry DOI: 10.2210/pdb7wmc/pdb
• Descriptor: Nicotinamide N-methyltransferase, Peptide1 (3 entities in total)
• Functional Keywords: nicotinamide n-methyltransferase, transferase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 5
• Total formula weight: 61416.57

Authors

Yoshida, S.,Uehara, S.,Kondo, N.,Takahashi, Y.,Yamamoto, S.,Kameda, A.,Kawagoe, S.,Inoue, N.,Yamada, M.,Yoshimura, N.,Tachibana, Y. (deposition date: 2022-01-14, release date: 2022-08-31, Last modification date: 2023-11-15)

• Primary citation: Yoshida, S.,Uehara, S.,Kondo, N.,Takahashi, Y.,Yamamoto, S.,Kameda, A.,Kawagoe, S.,Inoue, N.,Yamada, M.,Yoshimura, N.,Tachibana, Y.; Peptide-to-Small Molecule: A Pharmacophore-Guided Small Molecule Lead Generation Strategy from High-Affinity Macrocyclic Peptides.; J.Med.Chem., 65:10655-10673, 2022; PubMed: 35904556; DOI: 10.1021/acs.jmedchem.2c00919

Experimental method

X-RAY DIFFRACTION (2.55 Å)