7WKU

Structure of PDCoV Mpro in complex with an inhibitor

Summary for 7WKU

Entry DOI	10.2210/pdb7wku/pdb
Related PRD ID	PRD_002214
Descriptor	Peptidase C30, N-[(5-METHYLISOXAZOL-3-YL)CARBONYL]ALANYL-L-VALYL-N~1~-((1R,2Z)-4-(BENZYLOXY)-4-OXO-1-{[(3R)-2-OXOPYRROLIDIN-3-YL]METHYL}BUT-2-ENYL)-L-LEUCINAMIDE (3 entities in total)
Functional Keywords	virus, viral protease, drug design, inhibitor, broad-spectrum antivirals, viral protein
Biological source	Porcine deltacoronavirus More
Total number of polymer chains	12
Total formula weight	212101.30
Authors	Wang, F.H.,Yang, H.T. (deposition date: 2022-01-11, release date: 2022-05-25, Last modification date: 2023-11-29)
Primary citation	Wang, F.,Chen, C.,Wang, Z.,Han, X.,Shi, P.,Zhou, K.,Liu, X.,Xiao, Y.,Cai, Y.,Huang, J.,Zhang, L.,Yang, H. The Structure of the Porcine Deltacoronavirus Main Protease Reveals a Conserved Target for the Design of Antivirals. Viruses, 14:-, 2022 Cited by PubMed: 35336895 DOI: 10.3390/v14030486 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation