7WKU

Structure of PDCoV Mpro in complex with an inhibitor

7WKU の概要

• エントリーDOI: 10.2210/pdb7wku/pdb
• 関連するBIRD辞書のPRD_ID: PRD_002214
• 分子名称: Peptidase C30, N-[(5-METHYLISOXAZOL-3-YL)CARBONYL]ALANYL-L-VALYL-N~1~-((1R,2Z)-4-(BENZYLOXY)-4-OXO-1-{[(3R)-2-OXOPYRROLIDIN-3-YL]METHYL}BUT-2-ENYL)-L-LEUCINAMIDE (3 entities in total)
• 機能のキーワード: virus, viral protease, drug design, inhibitor, broad-spectrum antivirals, viral protein
• 由来する生物種: Porcine deltacoronavirus; 詳細
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 212101.30

構造登録者

Wang, F.H.,Yang, H.T. (登録日: 2022-01-11, 公開日: 2022-05-25, 最終更新日: 2023-11-29)

• 主引用文献: Wang, F.,Chen, C.,Wang, Z.,Han, X.,Shi, P.,Zhou, K.,Liu, X.,Xiao, Y.,Cai, Y.,Huang, J.,Zhang, L.,Yang, H.; The Structure of the Porcine Deltacoronavirus Main Protease Reveals a Conserved Target for the Design of Antivirals.; Viruses, 14:-, 2022; PubMed: 35336895; DOI: 10.3390/v14030486

実験手法

X-RAY DIFFRACTION (2.6 Å)