7WI6

Cryo-EM structure of LY341495/NAM-bound mGlu3

Summary for 7WI6

Entry DOI	10.2210/pdb7wi6/pdb
EMDB information	32526
Descriptor	Metabotropic glutamate receptor 3, 2-[(1S,2S)-2-carboxycyclopropyl]-3-(9H-xanthen-9-yl)-D-alanine, 2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total)
Functional Keywords	glutamate, g protein-coupled receptor, cryo-em, selective ligand, membrane protein
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	201192.54
Authors	Fang, W.,Yang, F.,Xu, C.J.,Ling, S.L.,Lin, L.,Zhou, Y.X.,Sun, W.J.,Wang, X.M.,Liu, P.,Rondard, P.,Pan, S.,Pin, J.P.,Tian, C.L.,Liu, J.F. (deposition date: 2022-01-03, release date: 2022-03-16, Last modification date: 2022-07-20)
Primary citation	Fang, W.,Yang, F.,Xu, C.,Ling, S.,Lin, L.,Zhou, Y.,Sun, W.,Wang, X.,Liu, P.,Rondard, P.,Shi, P.,Pin, J.P.,Tian, C.,Liu, J. Structural basis of the activation of metabotropic glutamate receptor 3. Cell Res., 32:695-698, 2022 Cited by PubMed: 35236939 DOI: 10.1038/s41422-022-00623-z PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.71 Å)

Structure validation