7WGP

X-ray structure of human PPAR gamma ligand binding domain-fenofibric acid co-crystals obtained by co-crystallization

Summary for 7WGP

• Entry DOI: 10.2210/pdb7wgp/pdb
• Descriptor: Isoform 1 of Peroxisome proliferator-activated receptor gamma, 15-meric peptide from Nuclear receptor coactivator 1, 2-[4-(4-chlorobenzene-1-carbonyl)phenoxy]-2-methylpropanoic acid (3 entities in total)
• Functional Keywords: nuclear receptor, protein-ligand complex, ppar, transcription
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 34667.43

Authors

Kamata, S.,Honda, A.,Akahane, M.,Machida, Y.,Uchii, K.,Shiiyama, Y.,Masuda, R.,Oyama, T.,Ishii, I. (deposition date: 2021-12-28, release date: 2022-05-25, Last modification date: 2023-11-29)

• Primary citation: Honda, A.,Kamata, S.,Akahane, M.,Machida, Y.,Uchii, K.,Shiiyama, Y.,Habu, Y.,Miyawaki, S.,Kaneko, C.,Oyama, T.,Ishii, I.; Functional and Structural Insights into Human PPAR alpha / delta / gamma Subtype Selectivity of Bezafibrate, Fenofibric Acid, and Pemafibrate.; Int J Mol Sci, 23:-, 2022; PubMed: 35563117; DOI: 10.3390/ijms23094726

Experimental method

X-RAY DIFFRACTION (2.53 Å)