7WGN
X-ray structure of human PPAR delta ligand binding domain-pemafibrate co-crystals obtained by co-crystallization
Summary for 7WGN
Entry DOI | 10.2210/pdb7wgn/pdb |
Descriptor | Peroxisome proliferator-activated receptor delta, (2~{R})-2-[3-[[1,3-benzoxazol-2-yl-[3-(4-methoxyphenoxy)propyl]amino]methyl]phenoxy]butanoic acid, octyl beta-D-glucopyranoside, ... (4 entities in total) |
Functional Keywords | nuclear receptor, protein-ligand complex, ppar, transcription |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 32310.56 |
Authors | Kamata, S.,Honda, A.,Akahane, M.,Machida, Y.,Uchii, K.,Shiiyama, Y.,Masuda, R.,Oyama, T.,Ishii, I. (deposition date: 2021-12-28, release date: 2022-05-25, Last modification date: 2023-11-29) |
Primary citation | Honda, A.,Kamata, S.,Akahane, M.,Machida, Y.,Uchii, K.,Shiiyama, Y.,Habu, Y.,Miyawaki, S.,Kaneko, C.,Oyama, T.,Ishii, I. Functional and Structural Insights into Human PPAR alpha / delta / gamma Subtype Selectivity of Bezafibrate, Fenofibric Acid, and Pemafibrate. Int J Mol Sci, 23:-, 2022 Cited by PubMed: 35563117DOI: 10.3390/ijms23094726 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.813 Å) |
Structure validation
Download full validation report