7WGL

X-ray structure of human PPAR delta ligand binding domain-bezafibrate co-crystals obtained by co-crystallization

Summary for 7WGL

• Entry DOI: 10.2210/pdb7wgl/pdb
• Descriptor: Peroxisome proliferator-activated receptor delta, octyl beta-D-glucopyranoside, 2-[P-[2-P-CHLOROBENZAMIDO)ETHYL]PHENOXY]-2-METHYLPROPIONIC ACID, ... (4 entities in total)
• Functional Keywords: nuclear receptor, protein-ligand complex, ppar, transcription
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 64363.67

Authors

Kamata, S.,Honda, A.,Machida, Y.,Uchii, K.,Shiiyama, Y.,Masuda, R.,Oyama, T.,Ishii, I. (deposition date: 2021-12-28, release date: 2022-05-25, Last modification date: 2023-11-29)

• Primary citation: Honda, A.,Kamata, S.,Akahane, M.,Machida, Y.,Uchii, K.,Shiiyama, Y.,Habu, Y.,Miyawaki, S.,Kaneko, C.,Oyama, T.,Ishii, I.; Functional and Structural Insights into Human PPAR alpha / delta / gamma Subtype Selectivity of Bezafibrate, Fenofibric Acid, and Pemafibrate.; Int J Mol Sci, 23:-, 2022; PubMed: 35563117; DOI: 10.3390/ijms23094726

Experimental method

X-RAY DIFFRACTION (2.091 Å)