7WF5
c-Src in complex with ponatinib
Summary for 7WF5
Entry DOI | 10.2210/pdb7wf5/pdb |
Descriptor | Proto-oncogene tyrosine-protein kinase Src, 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzam ide (3 entities in total) |
Functional Keywords | inhibitor, kinase, oncoprotein |
Biological source | Gallus gallus (chicken) |
Total number of polymer chains | 2 |
Total formula weight | 66518.41 |
Authors | |
Primary citation | Guo, M.,Duan, Y.,Dai, S.,Li, J.,Chen, X.,Qu, L.,Chen, Z.,Wei, H.,Jiang, L.,Chen, Y. Structural study of ponatinib in inhibiting SRC kinase. Biochem.Biophys.Res.Commun., 598:15-19, 2022 Cited by PubMed: 35151199DOI: 10.1016/j.bbrc.2022.02.001 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.798 Å) |
Structure validation
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