7WE4

Human Nav1.8 with A-803467, class I

7WE4 の概要

• エントリーDOI: 10.2210/pdb7we4/pdb
• EMDBエントリー: 32439
• 分子名称: Sodium channel protein type 10 subunit alpha, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
• 機能のキーワード: voltage-gated sodium channel, nav, activation, selectivity, membrane protein
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 235228.53

構造登録者

Yan, N.,Pan, X.J.,Huang, X.S.,Huang, G.X. (登録日: 2021-12-22, 公開日: 2022-08-03, 最終更新日: 2022-09-21)

• 主引用文献: Huang, X.,Jin, X.,Huang, G.,Huang, J.,Wu, T.,Li, Z.,Chen, J.,Kong, F.,Pan, X.,Yan, N.; Structural basis for high-voltage activation and subtype-specific inhibition of human Na v 1.8.; Proc.Natl.Acad.Sci.USA, 119:e2208211119-e2208211119, 2022; PubMed: 35858452; DOI: 10.1073/pnas.2208211119

実験手法

ELECTRON MICROSCOPY (2.7 Å)