7WCV
Co-crystal structure of FTO bound to 6e
Summary for 7WCV
| Entry DOI | 10.2210/pdb7wcv/pdb |
| Descriptor | Alpha-ketoglutarate-dependent dioxygenase FTO, 2-OXOGLUTARIC ACID, MANGANESE (II) ION, ... (5 entities in total) |
| Functional Keywords | rna demethylase, rna binding protein, oxidoreductase |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 1 |
| Total formula weight | 57020.88 |
| Authors | Yang, C.-G.,Gan, J.H. (deposition date: 2021-12-20, release date: 2022-07-06, Last modification date: 2023-11-29) |
| Primary citation | Liu, Z.,Duan, Z.,Zhang, D.,Xiao, P.,Zhang, T.,Xu, H.,Wang, C.H.,Rao, G.W.,Gan, J.,Huang, Y.,Yang, C.G.,Dong, Z. Structure-Activity Relationships and Antileukemia Effects of the Tricyclic Benzoic Acid FTO Inhibitors. J.Med.Chem., 65:10638-10654, 2022 Cited by PubMed: 35793358DOI: 10.1021/acs.jmedchem.2c00848 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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