7WCM
Cryo-EM structure of GPR119-Gs Complex with small molecule agonist MBX-2982
Summary for 7WCM
Entry DOI | 10.2210/pdb7wcm/pdb |
EMDB information | 32424 |
Descriptor | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total) |
Functional Keywords | gpcr, signaling protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 5 |
Total formula weight | 144814.96 |
Authors | Qiao, A.N.,Wu, S.,Ye, S. (deposition date: 2021-12-20, release date: 2022-12-21, Last modification date: 2022-12-28) |
Primary citation | Qian, Y.,Wang, J.,Yang, L.,Liu, Y.,Wang, L.,Liu, W.,Lin, Y.,Yang, H.,Ma, L.,Ye, S.,Wu, S.,Qiao, A. Activation and signaling mechanism revealed by GPR119-G s complex structures. Nat Commun, 13:7033-7033, 2022 Cited by PubMed: 36396650DOI: 10.1038/s41467-022-34696-6 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.33 Å) |
Structure validation
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