7WCL

Crystal structure of FGFR1 kinase domain with Pemigatinib

7WCL の概要

• エントリーDOI: 10.2210/pdb7wcl/pdb
• 分子名称: Fibroblast growth factor receptor 1, 11-[2,6-bis(fluoranyl)-3,5-dimethoxy-phenyl]-13-ethyl-4-(morpholin-4-ylmethyl)-5,7,11,13-tetrazatricyclo[7.4.0.0^{2,6}]trideca-1(9),2(6),3,7-tetraen-12-one, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: kinase, inhibitor, complex, structural protein, transferase-transferase inhibitor complex, tra, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 72080.42

構造登録者

Chen, X.J.,Lin, Q.M.,Jiang, L.Y.,Qu, L.Z.,Chen, Y.H. (登録日: 2021-12-20, 公開日: 2022-09-14, 最終更新日: 2023-11-29)

• 主引用文献: Lin, Q.,Chen, X.,Qu, L.,Guo, M.,Wei, H.,Dai, S.,Jiang, L.,Chen, Y.; Characterization of the cholangiocarcinoma drug pemigatinib against FGFR gatekeeper mutants.; Commun Chem, 5:100-100, 2022; PubMed: 36698015; DOI: 10.1038/s42004-022-00718-z

実験手法

X-RAY DIFFRACTION (2.495 Å)