7WBJ

Cryo-EM structure of N-terminal modified human vasoactive intestinal polypeptide receptor 2 (VIP2R) in complex with PACAP27 and Gs

7WBJ の概要

• エントリーDOI: 10.2210/pdb7wbj/pdb
• EMDBエントリー: 32401
• 分子名称: Vasoactive intestinal polypeptide receptor 2, Pituitary adenylate cyclase-activating polypeptide 27, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... (6 entities in total)
• 機能のキーワード: vasoactive intestinal polypeptide receptor 2, g protein-coupled receptor, ligand recognition, structural protein
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 164981.65

構造登録者

Xu, Y.N.,Feng, W.B.,Zhou, Q.T.,Liang, A.Y.,Li, J.,Dai, A.T.,Zhao, F.H.,Yan, J.H.,Chen, C.W.,Li, H.,Zhao, L.H.,Xia, T.,Jiang, Y.,Xu, H.E.,Yang, D.H.,Wang, M.W. (登録日: 2021-12-16, 公開日: 2022-05-18)

• 主引用文献: Xu, Y.,Feng, W.,Zhou, Q.,Liang, A.,Li, J.,Dai, A.,Zhao, F.,Yan, J.,Chen, C.W.,Li, H.,Zhao, L.H.,Xia, T.,Jiang, Y.,Xu, H.E.,Yang, D.,Wang, M.W.; A distinctive ligand recognition mechanism by the human vasoactive intestinal polypeptide receptor 2.; Nat Commun, 13:2272-2272, 2022; PubMed: 35477937; DOI: 10.1038/s41467-022-30041-z

実験手法

ELECTRON MICROSCOPY (3.42 Å)