7W9P
Cryo-EM structure of human Nav1.7(E406K) in complex with auxiliary beta subunits, huwentoxin-IV and saxitoxin (S6IV pi helix conformer)
Summary for 7W9P
Entry DOI | 10.2210/pdb7w9p/pdb |
EMDB information | 32371 |
Descriptor | Sodium channel protein type 9 subunit alpha, (2S,3R,4E)-2-(acetylamino)-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... (11 entities in total) |
Functional Keywords | nav1.7, scn9a, cryo-em, membrane protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 3 |
Total formula weight | 299271.32 |
Authors | |
Primary citation | Huang, G.,Liu, D.,Wang, W.,Wu, Q.,Chen, J.,Pan, X.,Shen, H.,Yan, N. High-resolution structures of human Na v 1.7 reveal gating modulation through alpha-pi helical transition of S6 IV. Cell Rep, 39:110735-110735, 2022 Cited by PubMed: 35476982DOI: 10.1016/j.celrep.2022.110735 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.9 Å) |
Structure validation
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