7W7X

The crystal structure of human abl1 kinase domain in complex with ABL1-A11

Summary for 7W7X

Entry DOI	10.2210/pdb7w7x/pdb
Descriptor	Tyrosine-protein kinase ABL1, 5-[5-(dimethylcarbamoyl)pyridin-3-yl]-3-(5-fluorosulfonyloxy-2-methoxy-phenyl)-1H-pyrrolo[2,3-b]pyridine (3 entities in total)
Functional Keywords	abl1, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	64259.21
Authors	Zhu, C.,Zhang, Z.M. (deposition date: 2021-12-06, release date: 2022-04-27, Last modification date: 2023-11-29)
Primary citation	Chen, P.,Sun, J.,Zhu, C.,Tang, G.,Wang, W.,Xu, M.,Xiang, M.,Zhang, C.J.,Zhang, Z.M.,Gao, L.,Yao, S.Q. Cell-Active, Reversible, and Irreversible Covalent Inhibitors That Selectively Target the Catalytic Lysine of BCR-ABL Kinase. Angew.Chem.Int.Ed.Engl., 61:e202203878-e202203878, 2022 Cited by PubMed: 35438229 DOI: 10.1002/anie.202203878 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.00000937681 Å)

Structure validation