7W40

Cryo-EM Structure of Human Gastrin Releasing Peptide Receptor in complex with the agonist Bombesin (6-14) [D-Phe6, beta-Ala11, Phe13, Nle14] and Gq heterotrimers

7W40 の概要

• エントリーDOI: 10.2210/pdb7w40/pdb
• EMDBエントリー: 32298
• 分子名称: Maltodextrin-binding protein,Gastrin-releasing peptide receptor, Guanine nucleotide-binding protein G(q) subunit alpha, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... (6 entities in total)
• 機能のキーワード: gpcr, gastrin releasing peptide receptor, membrane protein
• 由来する生物種: Escherichia coli; 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 225273.58

構造登録者

Zhan, Y.,Peng, S.,Zhang, H. (登録日: 2021-11-26, 公開日: 2023-02-22)

• 主引用文献: Peng, S.,Zhan, Y.,Zhang, D.,Ren, L.,Chen, A.,Chen, Z.F.,Zhang, H.; Structures of human gastrin-releasing peptide receptors bound to antagonist and agonist for cancer and itch therapy.; Proc.Natl.Acad.Sci.USA, 120:e2216230120-e2216230120, 2023; PubMed: 36724251; DOI: 10.1073/pnas.2216230120

実験手法

ELECTRON MICROSCOPY (3 Å)