7W3Z

Cryo-EM Structure of Human Gastrin Releasing Peptide Receptor in complex with the agonist Gastrin Releasing Peptide and Gq heterotrimers

Summary for 7W3Z

Entry DOI	10.2210/pdb7w3z/pdb
EMDB information	32297
Descriptor	Maltodextrin-binding protein,Gastrin-releasing peptide receptor, Gastrin Releasing Peptide PRGNHWAVGHLM(NH2), Guanine nucleotide-binding protein G(q) subunit alpha, ... (6 entities in total)
Functional Keywords	gpcr, gastrin releasing peptide receptor, membrane protein
Biological source	Escherichia coli More
Total number of polymer chains	6
Total formula weight	225530.88
Authors	Zhan, Y.,Peng, S.,Zhang, H. (deposition date: 2021-11-26, release date: 2023-02-22)
Primary citation	Peng, S.,Zhan, Y.,Zhang, D.,Ren, L.,Chen, A.,Chen, Z.F.,Zhang, H. Structures of human gastrin-releasing peptide receptors bound to antagonist and agonist for cancer and itch therapy. Proc.Natl.Acad.Sci.USA, 120:e2216230120-e2216230120, 2023 Cited by PubMed: 36724251 DOI: 10.1073/pnas.2216230120 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3 Å)

Structure validation