7W3L
Crystal structure of LSD1 in complex with cis-4-Br-2,5-F2-PCPA (S1024)
Summary for 7W3L
Entry DOI | 10.2210/pdb7w3l/pdb |
Descriptor | Lysine-specific histone demethylase 1A, FLAVIN-ADENINE DINUCLEOTIDE, 3-[4-bromanyl-2,5-bis(fluoranyl)phenyl]propanal, ... (6 entities in total) |
Functional Keywords | demethylase, amine oxidase, chromatin, histone, fad, mechanism-based inhibitor, oxidoreductase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 76070.29 |
Authors | Niwa, H.,Sato, S.,Umehara, T. (deposition date: 2021-11-25, release date: 2022-09-14, Last modification date: 2023-11-29) |
Primary citation | Niwa, H.,Watanabe, C.,Sato, S.,Harada, T.,Watanabe, H.,Tabusa, R.,Fukasawa, S.,Shiobara, A.,Hashimoto, T.,Ohno, O.,Nakamura, K.,Tsuganezawa, K.,Tanaka, A.,Shirouzu, M.,Honma, T.,Matsuno, K.,Umehara, T. Structure-Activity Relationship and In Silico Evaluation of cis- and trans-PCPA-Derived Inhibitors of LSD1 and LSD2 Acs Med.Chem.Lett., 13:1485-1492, 2022 Cited by DOI: 10.1021/acsmedchemlett.2c00294PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.51 Å) |
Structure validation
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