7W3L

Crystal structure of LSD1 in complex with cis-4-Br-2,5-F2-PCPA (S1024)

7W3L の概要

• エントリーDOI: 10.2210/pdb7w3l/pdb
• 分子名称: Lysine-specific histone demethylase 1A, FLAVIN-ADENINE DINUCLEOTIDE, 3-[4-bromanyl-2,5-bis(fluoranyl)phenyl]propanal, ... (6 entities in total)
• 機能のキーワード: demethylase, amine oxidase, chromatin, histone, fad, mechanism-based inhibitor, oxidoreductase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 76070.29

構造登録者

Niwa, H.,Sato, S.,Umehara, T. (登録日: 2021-11-25, 公開日: 2022-09-14, 最終更新日: 2023-11-29)

• 主引用文献: Niwa, H.,Watanabe, C.,Sato, S.,Harada, T.,Watanabe, H.,Tabusa, R.,Fukasawa, S.,Shiobara, A.,Hashimoto, T.,Ohno, O.,Nakamura, K.,Tsuganezawa, K.,Tanaka, A.,Shirouzu, M.,Honma, T.,Matsuno, K.,Umehara, T.; Structure-Activity Relationship and In Silico Evaluation of cis- and trans-PCPA-Derived Inhibitors of LSD1 and LSD2; Acs Med.Chem.Lett., 13:1485-1492, 2022; DOI: 10.1021/acsmedchemlett.2c00294

実験手法

X-RAY DIFFRACTION (2.51 Å)