7VZN

The structure of GdmN in complex with carbamoyl adenylate intermediate and 20-O-methyl-19-chloroproansamitocin

Summary for 7VZN

• Entry DOI: 10.2210/pdb7vzn/pdb
• Descriptor: GdmN, FE (III) ION, (5~{S},6~{E},8~{S},9~{S},12~{R},15~{E})-21-chloranyl-12,20-dimethoxy-6,8,16-trimethyl-5,9-bis(oxidanyl)-2-azabicyclo[16.3.1]docosa-1(21),6,15,18(22),19-pentaene-3,11-dione, ... (10 entities in total)
• Functional Keywords: homodimer, carbamoyltransferase, ansamycins antibiotics, transferase
• Biological source: Streptomyces hygroscopicus
• Total number of polymer chains: 2
• Total formula weight: 152071.74

Authors

Wei, J.,Zheng, J.,Zhou, J.,Kang, Q.,Bai, L. (deposition date: 2021-11-16, release date: 2022-11-16, Last modification date: 2023-11-29)

• Primary citation: Wei, J.,Zhang, X.,Zhou, Y.,Cheng, X.,Lin, Z.,Tang, M.,Zheng, J.,Wang, B.,Kang, Q.,Bai, L.; Endowing homodimeric carbamoyltransferase GdmN with iterative functions through structural characterization and mechanistic studies.; Nat Commun, 13:6617-6617, 2022; PubMed: 36329057; DOI: 10.1038/s41467-022-34387-2

Experimental method

X-RAY DIFFRACTION (2.1 Å)