7VXG

Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitor TK-453

7VXG の概要

• エントリーDOI: 10.2210/pdb7vxg/pdb
• 分子名称: Tyrosine-protein phosphatase non-receptor type 11, 6-[4-(aminomethyl)-4-methyl-piperidin-1-yl]-3-[2,3-bis(chloranyl)phenyl]sulfanyl-pyrazin-2-amine (3 entities in total)
• 機能のキーワード: protein tyrosine phosphatase, shp2, inhibitor, complex, antitumor protein
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 242933.55

構造登録者

Li, T.H.,Guo, H.T.,Ji, X.Y. (登録日: 2021-11-12, 公開日: 2022-03-23, 最終更新日: 2023-11-29)

• 主引用文献: Wang, M.,Li, T.,Ouyang, Z.,Tang, K.,Zhu, Y.,Song, C.,Sun, H.,Yu, B.,Ji, X.,Sun, Y.; SHP2 allosteric inhibitor TK-453 alleviates psoriasis-like skin inflammation in mice via inhibition of IL-23/Th17 axis.; Iscience, 25:104009-104009, 2022; PubMed: 35310939; DOI: 10.1016/j.isci.2022.104009

実験手法

X-RAY DIFFRACTION (2.1 Å)