7VVJ

PTHrP-bound human PTH1R in complex with Gs

Summary for 7VVJ

Entry DOI	10.2210/pdb7vvj/pdb
EMDB information	32141
Descriptor	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total)
Functional Keywords	g protein-coupled receptor, membrane protein, signaling protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	6
Total formula weight	165027.68
Authors	Kobayashi, K.,Kusakizako, T.,Miyauchi, H.,Tomita, A.,Kobayashi, K.,Shihoya, W.,Yamashita, K.,Nishizawa, T.,Kato, H.E.,Nureki, O. (deposition date: 2021-11-06, release date: 2022-08-03, Last modification date: 2023-02-15)
Primary citation	Kobayashi, K.,Kawakami, K.,Kusakizako, T.,Miyauchi, H.,Tomita, A.,Kobayashi, K.,Shihoya, W.,Yamashita, K.,Nishizawa, T.,Kato, H.E.,Inoue, A.,Nureki, O. Endogenous ligand recognition and structural transition of a human PTH receptor. Mol.Cell, 82:3468-3483.e5, 2022 Cited by PubMed: 35932760 DOI: 10.1016/j.molcel.2022.07.003 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.2 Å)

Structure validation