7VUE

Structural insight of the molecular mechanism of cilofexor bound to FXR

7VUE の概要

• エントリーDOI: 10.2210/pdb7vue/pdb
• 分子名称: Bile acid receptor, Peptide from Nuclear receptor coactivator 2, 2-[3-[4-[[3-[2,6-bis(chloranyl)phenyl]-5-cyclopropyl-1,2-oxazol-4-yl]methoxy]-2-chloranyl-phenyl]-3-oxidanyl-azetidin-1-yl]pyridine-4-carboxylic acid, ... (4 entities in total)
• 機能のキーワード: nuclear receptor, ligand binding, nuclear protein
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 28742.19

構造登録者

Jiang, L.,Chen, Y.C. (登録日: 2021-11-02, 公開日: 2022-03-16, 最終更新日: 2023-11-29)

• 主引用文献: Jiang, L.,Liu, X.,Wei, H.,Dai, S.,Qu, L.,Chen, X.,Guo, M.,Chen, Y.; Structural insight into the molecular mechanism of cilofexor binding to the farnesoid X receptor.; Biochem.Biophys.Res.Commun., 595:1-6, 2022; PubMed: 35091108; DOI: 10.1016/j.bbrc.2022.01.069

実験手法

X-RAY DIFFRACTION (2.601 Å)