7VTV
Crystal structure of PDE8A catalytic domain in complex with 15
Summary for 7VTV
Entry DOI | 10.2210/pdb7vtv/pdb |
Descriptor | High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A, ZINC ION, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | camp-specific, hydrolase, selective pde8a inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 39585.47 |
Authors | Wu, X.-N.,Zhou, Q.,Huang, Y.-D.,Li, Z.,Wu, Y.,Luo, H.-B. (deposition date: 2021-10-31, release date: 2022-11-02, Last modification date: 2023-11-29) |
Primary citation | Wu, X.-N.,Zhou, Q.,Huang, Y.-D.,Li, Z.,Wu, Y.,Luo, H.-B. Structure-Based Discovery of Orally Efficient PDE8 Inhibitors for the Treatment of Vascular Dementia To Be Published, |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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