7VTP

Cryo-EM structure of PYD-deleted human NLRP3 hexamer

Summary for 7VTP

• Entry DOI: 10.2210/pdb7vtp/pdb
• EMDB information: 32119
• Descriptor: NACHT, LRR and PYD domains-containing protein 3, ADENOSINE-5'-DIPHOSPHATE, 1-[4-(2-oxidanylpropan-2-yl)furan-2-yl]sulfonyl-3-(1,2,3,5-tetrahydro-s-indacen-4-yl)urea (3 entities in total)
• Functional Keywords: nlr, nod-like receptor, nlrp3, inflammasome, immune system
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 6
• Total formula weight: 642769.22

Authors

Ohto, U.,Shimizu, T. (deposition date: 2021-10-30, release date: 2022-03-09, Last modification date: 2024-06-26)

• Primary citation: Ohto, U.,Kamitsukasa, Y.,Ishida, H.,Zhang, Z.,Murakami, K.,Hirama, C.,Maekawa, S.,Shimizu, T.; Structural basis for the oligomerization-mediated regulation of NLRP3 inflammasome activation.; Proc.Natl.Acad.Sci.USA, 119:e2121353119-e2121353119, 2022; PubMed: 35254907; DOI: 10.1073/pnas.2121353119

Experimental method

ELECTRON MICROSCOPY (3.23 Å)