7VRO

crystal structure of BRD2-BD1 in complex with purine derivative

7VRO の概要

• エントリーDOI: 10.2210/pdb7vro/pdb
• 分子名称: Bromodomain-containing protein 2, THEOBROMINE, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: bet family, bet inhibitor, bromodomain inhibitor, brd2-bd1 inhibitor, transcription-inhibitor complex, transcription/inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 45760.93

構造登録者

Padmanabhan, B.,Arole, A.,Deshmukh, P.,Ashok, S.,Mathur, S. (登録日: 2021-10-23, 公開日: 2023-02-01, 最終更新日: 2023-11-29)

• 主引用文献: Arole, A.H.,Deshmukh, P.,Sridhar, A.,Mathur, S.,Mahalingaswamy, M.,Subramanya, H.,Dalavaikodihalli Nanjaiah, N.,Padmanabhan, B.; Structural and biochemical insights into purine-based drug molecules in hBRD2 delineate a unique binding mode opening new vistas in the design of inhibitors of the BET family.; Acta Crystallogr D Struct Biol, 79:758-774, 2023; PubMed: 37432115; DOI: 10.1107/S2059798323005211

実験手法

X-RAY DIFFRACTION (2.35 Å)