7VRO
crystal structure of BRD2-BD1 in complex with purine derivative
7VRO の概要
エントリーDOI | 10.2210/pdb7vro/pdb |
分子名称 | Bromodomain-containing protein 2, THEOBROMINE, SULFATE ION, ... (4 entities in total) |
機能のキーワード | bet family, bet inhibitor, bromodomain inhibitor, brd2-bd1 inhibitor, transcription-inhibitor complex, transcription/inhibitor |
由来する生物種 | Homo sapiens (Human) |
タンパク質・核酸の鎖数 | 3 |
化学式量合計 | 45760.93 |
構造登録者 | Padmanabhan, B.,Arole, A.,Deshmukh, P.,Ashok, S.,Mathur, S. (登録日: 2021-10-23, 公開日: 2023-02-01, 最終更新日: 2023-11-29) |
主引用文献 | Arole, A.H.,Deshmukh, P.,Sridhar, A.,Mathur, S.,Mahalingaswamy, M.,Subramanya, H.,Dalavaikodihalli Nanjaiah, N.,Padmanabhan, B. Structural and biochemical insights into purine-based drug molecules in hBRD2 delineate a unique binding mode opening new vistas in the design of inhibitors of the BET family. Acta Crystallogr D Struct Biol, 79:758-774, 2023 Cited by PubMed: 37432115DOI: 10.1107/S2059798323005211 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.35 Å) |
構造検証レポート
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