7VRE

The crystal structure of EGFR T790M/C797S with the inhibitor HCD2892

7VRE の概要

• エントリーDOI: 10.2210/pdb7vre/pdb
• 分子名称: Epidermal growth factor receptor, 5-chloranyl-N-[5-chloranyl-2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]-4-(1-ethylsulfonylindol-3-yl)pyrimidin-2-amine (3 entities in total)
• 機能のキーワード: egfr, inhibitor, complex, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 38119.00

構造登録者

Zhu, S.J. (登録日: 2021-10-22, 公開日: 2022-06-08, 最終更新日: 2023-11-29)

• 主引用文献: Chen, H.,Lai, M.,Zhang, T.,Chen, Y.,Tong, L.,Zhu, S.,Zhou, Y.,Ren, X.,Ding, J.,Xie, H.,Lu, X.,Ding, K.; Conformational Constrained 4-(1-Sulfonyl-3-indol)yl-2-phenylaminopyrimidine Derivatives as New Fourth-Generation Epidermal Growth Factor Receptor Inhibitors Targeting T790M/C797S Mutations.; J.Med.Chem., 65:6840-6858, 2022; PubMed: 35446588; DOI: 10.1021/acs.jmedchem.2c00168

実験手法

X-RAY DIFFRACTION (2.507 Å)