7VRA
The crystal structure of EGFR T790M/C797S with the inhibitor HC5476
Summary for 7VRA
Entry DOI | 10.2210/pdb7vra/pdb |
Descriptor | Epidermal growth factor receptor, 25-chloro-11-(ethylsulfonyl)-44-morpholino-11H-5,12-dioxa-3-aza-1(3,6)-indola-2(4,2)-pyrimidina-4(1,3)-benzenacyclododecaphane (3 entities in total) |
Functional Keywords | egfr, inhibitor, complex, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 38072.50 |
Authors | Zhu, S.J. (deposition date: 2021-10-22, release date: 2022-06-08, Last modification date: 2023-11-29) |
Primary citation | Chen, H.,Lai, M.,Zhang, T.,Chen, Y.,Tong, L.,Zhu, S.,Zhou, Y.,Ren, X.,Ding, J.,Xie, H.,Lu, X.,Ding, K. Conformational Constrained 4-(1-Sulfonyl-3-indol)yl-2-phenylaminopyrimidine Derivatives as New Fourth-Generation Epidermal Growth Factor Receptor Inhibitors Targeting T790M/C797S Mutations. J.Med.Chem., 65:6840-6858, 2022 Cited by PubMed: 35446588DOI: 10.1021/acs.jmedchem.2c00168 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.41 Å) |
Structure validation
Download full validation report