7VM4

Crystal structure of uPA in complex with nafamostat

Summary for 7VM4

Entry DOI	10.2210/pdb7vm4/pdb
Descriptor	Urokinase-type plasminogen activator, 4-carbamimidamidobenzoic acid, TRIETHYLENE GLYCOL, ... (4 entities in total)
Functional Keywords	upa, serine protease, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	28065.94
Authors	Jiang, L.G.,Huang, M.D. (deposition date: 2021-10-07, release date: 2022-10-12, Last modification date: 2023-11-29)
Primary citation	Zhou, Y.,Wu, J.,Xue, G.,Li, J.,Jiang, L.,Huang, M. Structural study of the uPA-nafamostat complex reveals a covalent inhibitory mechanism of nafamostat. Biophys.J., 121:3940-3949, 2022 Cited by PubMed: 36039386 DOI: 10.1016/j.bpj.2022.08.034 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.01 Å)

Structure validation