7VH8

Crystal structure of SARS-CoV-2 main protease in complex with protease inhibitor PF-07321332

7VH8 の概要

• エントリーDOI: 10.2210/pdb7vh8/pdb
• 分子名称: 3C-like proteinase, (1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide, DIMETHYL SULFOXIDE, ... (4 entities in total)
• 機能のキーワード: sars-cov-2, main protease, pf-07321332, viral protein
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV,SARS-CoV-2)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34405.22

構造登録者

Zhao, Y.,Zhang, Q.,Yang, H.,Rao, Z. (登録日: 2021-09-21, 公開日: 2021-11-03, 最終更新日: 2023-11-29)

• 主引用文献: Zhao, Y.,Fang, C.,Zhang, Q.,Zhang, R.,Zhao, X.,Duan, Y.,Wang, H.,Zhu, Y.,Feng, L.,Zhao, J.,Shao, M.,Yang, X.,Zhang, L.,Peng, C.,Yang, K.,Ma, D.,Rao, Z.,Yang, H.; Crystal structure of SARS-CoV-2 main protease in complex with protease inhibitor PF-07321332.; Protein Cell, 13:689-693, 2022; PubMed: 34687004; DOI: 10.1007/s13238-021-00883-2

実験手法

X-RAY DIFFRACTION (1.59 Å)