7VE2

Crystal Structure of Lopinavir bound Plasmepsin II (PMII) from Plasmodium falciparum

7VE2 の概要

• エントリーDOI: 10.2210/pdb7ve2/pdb
• 分子名称: Plasmepsin II, N-{1-BENZYL-4-[2-(2,6-DIMETHYL-PHENOXY)-ACETYLAMINO]-3-HYDROXY-5-PHENYL-PENTYL}-3-METHYL-2-(2-OXO-TETRAHYDRO-PYRIMIDIN-1-YL)-BUTYRAMIDE, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE (3 entities in total)
• 機能のキーワード: inhibitor, protease, peptidomimetic, hiv-1 protease inhibitor, peptidase, hemoglobin degrader, hydrolase
• 由来する生物種: Plasmodium falciparum (isolate 3D7)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 38972.48

構造登録者

Mishra, V.,Rathore, I.,Bhaumik, P. (登録日: 2021-09-07, 公開日: 2023-02-01, 最終更新日: 2024-03-06)

• 主引用文献: Mishra, V.,Deshmukh, A.,Rathore, I.,Chakraborty, S.,Patankar, S.,Gustchina, A.,Wlodawer, A.,Yada, R.Y.,Bhaumik, P.; Inhibition of Plasmodium falciparum plasmepsins by drugs targeting HIV-1 protease: A way forward for antimalarial drug discovery.; Curr Res Struct Biol, 7:100128-100128, 2024; PubMed: 38304146; DOI: 10.1016/j.crstbi.2024.100128

実験手法