7VD4

Crystal structure of BPTF-BRD with ligand TP248 bound

Summary for 7VD4

Entry DOI	10.2210/pdb7vd4/pdb
Descriptor	Nucleosome-remodeling factor subunit BPTF, 6-[4-[3-(dimethylamino)propoxy]phenyl]-N-methyl-2-methylsulfonyl-pyrimidin-4-amine (3 entities in total)
Functional Keywords	bptf bromodomain, lysine acetylation, small-molecule inhibitor, biosynthetic protein, antitumor protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	13750.75
Authors	Lu, T.,Lu, H.B. (deposition date: 2021-09-06, release date: 2022-09-14, Last modification date: 2023-11-29)
Primary citation	Lu, H.,Lu, T.,Zu, S.,Duan, Z.,Guang, Y.,Li, Q.,Ma, J.,Chen, D.,Li, B.,Lu, W.,Jiang, H.,Luo, C.,Ye, D.,Chen, K.,Lin, H. Discovery of a highly potent CECR2 bromodomain inhibitor with 7H-pyrrolo[2,3-d] pyrimidine scaffold. Bioorg.Chem., 123:105768-105768, 2022 Cited by PubMed: 35378372 DOI: 10.1016/j.bioorg.2022.105768 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.85659146555 Å)

Structure validation