7VD4

Crystal structure of BPTF-BRD with ligand TP248 bound

7VD4 の概要

• エントリーDOI: 10.2210/pdb7vd4/pdb
• 分子名称: Nucleosome-remodeling factor subunit BPTF, 6-[4-[3-(dimethylamino)propoxy]phenyl]-N-methyl-2-methylsulfonyl-pyrimidin-4-amine (3 entities in total)
• 機能のキーワード: bptf bromodomain, lysine acetylation, small-molecule inhibitor, biosynthetic protein, antitumor protein
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 13750.75

構造登録者

Lu, T.,Lu, H.B. (登録日: 2021-09-06, 公開日: 2022-09-14, 最終更新日: 2023-11-29)

• 主引用文献: Lu, H.,Lu, T.,Zu, S.,Duan, Z.,Guang, Y.,Li, Q.,Ma, J.,Chen, D.,Li, B.,Lu, W.,Jiang, H.,Luo, C.,Ye, D.,Chen, K.,Lin, H.; Discovery of a highly potent CECR2 bromodomain inhibitor with 7H-pyrrolo[2,3-d] pyrimidine scaffold.; Bioorg.Chem., 123:105768-105768, 2022; PubMed: 35378372; DOI: 10.1016/j.bioorg.2022.105768

実験手法

X-RAY DIFFRACTION (1.85659146555 Å)