7VBI

Cryo-EM structure of the non-acylated tirzepatide (LY3298176)-bound human GLP-1R-Gs complex

7VBI の概要

• エントリーDOI: 10.2210/pdb7vbi/pdb
• EMDBエントリー: 31880
• 分子名称: Isoform 3 of Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Nanobody 35, Non-acylated_tirzepatide, ... (6 entities in total)
• 機能のキーワード: cryo-electron microscopy; g protein-coupled receptor; ligand recognition; receptor activation; unimolecular agonist, structural protein
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 156795.19

構造登録者

Zhao, F.H.,Zhou, Q.T.,Cong, Z.T.,Hang, K.N.,Zou, X.Y.,Zhang, C.,Chen, Y.,Dai, A.T.,Liang, A.Y.,Ming, Q.Q.,Wang, M.,Chen, L.N.,Xu, P.Y.,Chang, R.L.,Feng, W.B.,Xia, T.,Zhang, Y.,Wu, B.L.,Yang, D.H.,Zhao, L.H.,Xu, H.E.,Wang, M.W. (登録日: 2021-08-31, 公開日: 2022-03-02, 最終更新日: 2022-03-16)

• 主引用文献: Zhao, F.,Zhou, Q.,Cong, Z.,Hang, K.,Zou, X.,Zhang, C.,Chen, Y.,Dai, A.,Liang, A.,Ming, Q.,Wang, M.,Chen, L.N.,Xu, P.,Chang, R.,Feng, W.,Xia, T.,Zhang, Y.,Wu, B.,Yang, D.,Zhao, L.,Xu, H.E.,Wang, M.W.; Structural insights into multiplexed pharmacological actions of tirzepatide and peptide 20 at the GIP, GLP-1 or glucagon receptors.; Nat Commun, 13:1057-1057, 2022; PubMed: 35217653; DOI: 10.1038/s41467-022-28683-0

実験手法

ELECTRON MICROSCOPY (3 Å)