7UZR

Structure of Ternary Complex of cGAS with dsDNA and Bound 5 -pppG(2 ,5 )pG

Summary for 7UZR

• Entry DOI: 10.2210/pdb7uzr/pdb
• Descriptor: Cyclic GMP-AMP synthase, Palindromic DNA18, [[(2~{R},3~{R},4~{R},5~{R})-5-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-4-[[(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-3-oxidanyl-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate, ... (6 entities in total)
• Functional Keywords: complex, pppgpg, manganese, immune system, transferase-dna complex, transferase/dna
• Biological source: Mus musculus (house mouse); More
• Total number of polymer chains: 6
• Total formula weight: 109426.26

Authors

Wu, S.,Gabelli, S.B.,Sohn, J. (deposition date: 2022-05-09, release date: 2023-05-10, Last modification date: 2024-05-22)

• Primary citation: Wu, S.,Gabelli, S.B.,Sohn, J.; The structural basis for 2'-5'/3'-5'-cGAMP synthesis by cGAS; Nat Commun, 15:4012-, 2024; DOI: 10.1038/s41467-024-48365-3

Experimental method

X-RAY DIFFRACTION (2.7 Å)