7UZR

Structure of Ternary Complex of cGAS with dsDNA and Bound 5 -pppG(2 ,5 )pG

7UZR の概要

• エントリーDOI: 10.2210/pdb7uzr/pdb
• 分子名称: Cyclic GMP-AMP synthase, Palindromic DNA18, [[(2~{R},3~{R},4~{R},5~{R})-5-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-4-[[(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-3-oxidanyl-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate, ... (6 entities in total)
• 機能のキーワード: complex, pppgpg, manganese, immune system, transferase-dna complex, transferase/dna
• 由来する生物種: Mus musculus (house mouse); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 109426.26

構造登録者

Wu, S.,Gabelli, S.B.,Sohn, J. (登録日: 2022-05-09, 公開日: 2023-05-10, 最終更新日: 2024-05-22)

• 主引用文献: Wu, S.,Gabelli, S.B.,Sohn, J.; The structural basis for 2'-5'/3'-5'-cGAMP synthesis by cGAS; Nat Commun, 15:4012-, 2024; DOI: 10.1038/s41467-024-48365-3

実験手法

X-RAY DIFFRACTION (2.7 Å)