7UZP

parathyroid hormone 1 receptor extracellular domain complexed with a peptide ligand containing three beta-amino acids

7UZP の概要

• エントリーDOI: 10.2210/pdb7uzp/pdb
• 分子名称: Parathyroid hormone/parathyroid hormone-related peptide receptor, PTHrP[1-36] 24,28,31 XCP, 1,2-ETHANEDIOL, ... (5 entities in total)
• 機能のキーワード: parathyroid hormone 1 receptor, signaling, beta-amino acid, signaling protein
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 44514.04

構造登録者

Yu, Z.,Bruchs, A.T.,Bingman, C.A.,Gellman, S.H. (登録日: 2022-05-09, 公開日: 2022-10-19, 最終更新日: 2024-02-28)

• 主引用文献: Liu, S.,Yu, Z.,Daley, E.J.,Bingman, C.A.,Bruchs, A.T.,Gardella, T.J.,Gellman, S.H.; Altered signaling at the PTH receptor via modified agonist contacts with the extracellular domain provides a path to prolonged agonism in vivo.; Proc.Natl.Acad.Sci.USA, 119:e2212736119-e2212736119, 2022; PubMed: 36409914; DOI: 10.1073/pnas.2212736119

実験手法

X-RAY DIFFRACTION (2.29 Å)