7UWP

Detergent-bound CYP51 from Acanthamoeba castellanii

7UWP の概要

• エントリーDOI: 10.2210/pdb7uwp/pdb
• 分子名称: sterol 14a-demethylase, PROTOPORPHYRIN IX CONTAINING FE, DODECYL-BETA-D-MALTOSIDE, ... (4 entities in total)
• 機能のキーワード: cytochrome p450, cyp51, sterol 14 alpha- demethylase, sterol biosynthesis, oxidoreductase
• 由来する生物種: Acanthamoeba castellanii
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 107148.85

構造登録者

Hargrove, T.Y.,Wawrzak, Z.,Lepesheva, G.I. (登録日: 2022-05-03, 公開日: 2023-04-12, 最終更新日: 2024-05-01)

• 主引用文献: Hargrove, T.Y.,Lamb, D.C.,Wawrzak, Z.,Hull, M.,Kelly, S.L.,Guengerich, F.P.,Lepesheva, G.I.; Identification of Potent and Selective Inhibitors of Acanthamoeba: Structural Insights into Sterol 14-Demethylase as a Key Drug Target; J.Med.Chem., 2024

実験手法

X-RAY DIFFRACTION (1.95 Å)