7UW4

Crystal structure of human Retinoid X receptor alpha ligand binding domain complex with UAB113 and coactivator peptide GRIP-1

7UW4 の概要

• エントリーDOI: 10.2210/pdb7uw4/pdb
• 分子名称: Retinoic acid receptor RXR-alpha, Nuclear receptor coactivator 2, (2E,4E,6Z,8E)-3,7-dimethyl-8-[2-(3-methylbutyl)-3-propylcyclohex-2-en-1-ylidene]octa-2,4,6-trienoic acid, ... (4 entities in total)
• 機能のキーワード: retinoid x receptor, retinoid x receptor alpha, ligand binding domain, coactivator complex, inhibitor complex, transcription
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 28792.45

構造登録者

Chattopadhyay, D.,Yang, Z.,Atigadda, V. (登録日: 2022-05-02, 公開日: 2023-03-15, 最終更新日: 2023-10-25)

• 主引用文献: Atigadda, V.R.,Kashyap, M.P.,Yang, Z.,Chattopadhyay, D.,Melo, N.,Sinha, R.,Belyaeva, O.V.,Chou, C.F.,Chang, P.L.,Kedishvili, N.Y.,Grubbs, C.J.,Renfrow, M.B.,Muccio, D.D.,Elmets, C.A.,Athar, M.; Conformationally Defined Rexinoids for the Prevention of Inflammation and Nonmelanoma Skin Cancers.; J.Med.Chem., 65:14409-14423, 2022; PubMed: 36318154; DOI: 10.1021/acs.jmedchem.2c00735

実験手法

X-RAY DIFFRACTION (2.1 Å)