7UW4
Crystal structure of human Retinoid X receptor alpha ligand binding domain complex with UAB113 and coactivator peptide GRIP-1
7UW4 の概要
エントリーDOI | 10.2210/pdb7uw4/pdb |
分子名称 | Retinoic acid receptor RXR-alpha, Nuclear receptor coactivator 2, (2E,4E,6Z,8E)-3,7-dimethyl-8-[2-(3-methylbutyl)-3-propylcyclohex-2-en-1-ylidene]octa-2,4,6-trienoic acid, ... (4 entities in total) |
機能のキーワード | retinoid x receptor, retinoid x receptor alpha, ligand binding domain, coactivator complex, inhibitor complex, transcription |
由来する生物種 | Homo sapiens (human) 詳細 |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 28792.45 |
構造登録者 | |
主引用文献 | Atigadda, V.R.,Kashyap, M.P.,Yang, Z.,Chattopadhyay, D.,Melo, N.,Sinha, R.,Belyaeva, O.V.,Chou, C.F.,Chang, P.L.,Kedishvili, N.Y.,Grubbs, C.J.,Renfrow, M.B.,Muccio, D.D.,Elmets, C.A.,Athar, M. Conformationally Defined Rexinoids for the Prevention of Inflammation and Nonmelanoma Skin Cancers. J.Med.Chem., 65:14409-14423, 2022 Cited by PubMed: 36318154DOI: 10.1021/acs.jmedchem.2c00735 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.1 Å) |
構造検証レポート
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