7UTY

First bromodomain of BRD4 liganded with compound 2c

7UTY の概要

• エントリーDOI: 10.2210/pdb7uty/pdb
• 分子名称: Bromodomain-containing protein 4, prop-2-en-1-yl (5S)-1-ethyl-7-methyl-5-(4-methylphenyl)-2,4-dioxo-1,2,3,4,5,8-hexahydropyrido[2,3-d]pyrimidine-6-carboxylate, 1,2-ETHANEDIOL, ... (4 entities in total)
• 機能のキーワード: inhibitor, acetyl-lysine, transcription regulation, transcription
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 15604.94

構造登録者

Schonbrunn, E.,Chan, A. (登録日: 2022-04-28, 公開日: 2022-08-24, 最終更新日: 2023-10-18)

• 主引用文献: Jiang, J.,Zhao, P.L.,Sigua, L.H.,Chan, A.,Schonbrunn, E.,Qi, J.,Georg, G.I.; 1,4-Dihydropyridinebutyrolactone-derived ring-opened ester and amide analogs targeting BET bromodomains.; Arch Pharm, 355:e2200288-e2200288, 2022; PubMed: 35941525; DOI: 10.1002/ardp.202200288

実験手法

X-RAY DIFFRACTION (1.55 Å)