7UTB

KPC-2 CARBAPENEMASE IN COMPLEX WITH THE BORONIC ACID INHIBITOR MB_076

7UTB の概要

• エントリーDOI: 10.2210/pdb7utb/pdb
• 分子名称: Carbapenem-hydrolyzing beta-lactamase KPC, [(1~{R})-1-[2-[(5-azanyl-1,3,4-thiadiazol-2-yl)sulfanyl]ethanoylamino]-2-(4-carboxy-1,2,3-triazol-1-yl)ethyl]-$l^{3}-oxidanyl-bis(oxidanyl)boron (3 entities in total)
• 機能のキーワード: beta-lactamase, carbapenemase, inhibitor complex, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor
• 由来する生物種: Klebsiella pneumoniae
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 28566.93

構造登録者

van den Akker, F.,Alsenani, T.A. (登録日: 2022-04-26, 公開日: 2022-12-14, 最終更新日: 2023-10-25)

• 主引用文献: Alsenani, T.A.,Rodriguez, M.M.,Ghiglione, B.,Taracila, M.A.,Mojica, M.F.,Rojas, L.J.,Hujer, A.M.,Gutkind, G.,Bethel, C.R.,Rather, P.N.,Introvigne, M.L.,Prati, F.,Caselli, E.,Power, P.,van den Akker, F.,Bonomo, R.A.; Boronic Acid Transition State Inhibitors as Potent Inactivators of KPC and CTX-M beta-Lactamases: Biochemical and Structural Analyses.; Antimicrob.Agents Chemother., 67:e0093022-e0093022, 2023; PubMed: 36602311; DOI: 10.1128/aac.00930-22

実験手法

X-RAY DIFFRACTION (1.38 Å)